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AD 1500
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Portuguese explorer Pedro Álvars Cabral reaches Brazil
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AD 1512
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Ferdinand annexes part of Navarre to Castile
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AD 1516
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Habsburg Charles I becomes king of Spain
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AD 1519
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Charles I becomes Holy Roman Emperor, Charles V
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AD 1521
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The Aztec Empire falls to Spanish conquistador Hernando Cortés
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AD 1521
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João III becomes king of Portugal and Algarves
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AD 1535
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Inca Empire in Peru and Chile fall to Spanish conquistador Francisco Pizarro
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AD 1536
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Portuguese Inquisition established on Spanish model
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AD 1540
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Ignatius of Loyola founds the Society of Jesus (Jesuits)
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AD 1543
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Francis I of France attacks Charles V in Netherlands and northern Spain
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AD 1545
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Council of Trent of the Roman Catholic church convenes as a response to challenges of the Protestant reformation
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AD 1554
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Felipe of Habsburg becomes king of Chile
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AD 1554
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Felipe of Habsburg marries Mary I of England; becomes king consort of England
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AD 1555
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Charles V, Holy Roman Emperor, grants control of the Netherlands to his son, Felipe of Habsburg
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AD 1556
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Abdication of Emperor Charles V; gives his Spanish domains to his son, Felipe
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AD 1556
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Felipe of Habsburg becomes King Felipe II of Spain
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AD 1557
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Sebastião becomes king of Portugal and Algarves
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AD 1557
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Mary I of England joins her husband Felipe II (Philip) of Spain in his war against France
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AD 1558
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Turks capture Balearic Islands from Spain and raid the mainland
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AD 1559
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Treaty of Cateau-Cambrésis: rule of Sicily and Milan granted to Spain
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AD 1561
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Felipe II establishes Madrid as capital of Spain
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AD 1566
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Beginning of war between Spain and Protestant United Provinces in northern Netherlands and their ally England
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AD 1568
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English fleet in the Caribbean under Sir Francis Drake plundered by Spanish ships
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AD 1576
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Spain captures Antwerp
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AD 1578
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Henrique becomes king of Portugal and Algarves
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AD 1580
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Death of Henrique; Felipe II of Spain seizes throne of Portugal and Algarves
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AD 1580
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António, Prior of Crato, makes an unsuccessful claim for the throne of Portugal and Algarves
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AD 1581
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Oath of Abjuration: United Provinces proclaim independence from Spain
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AD 1585
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England sends troops to aid Netherlands rebellion against Spanish rule; beginning of Anglo-Spanish War
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AD 1585
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Spanish possessions of Santo Domingo, Cartagena de Indias, and San Agustín in Florida are sacked by English under Sir Francis Drake
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AD 1587
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Spanish ships are burned at Cadiz by Sir Francis Drake
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AD 1587
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Felipe II gains papal authority to overthrow Elizabeth I of England
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AD 1588
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Spain sends Armada to invade England; it is defeated by the English navy
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AD 1589
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Spanish Atlantic navy torched by English fleet
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AD 1595
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France declares war on Spain; Spain driven out of Burgundy
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AD 1595
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Spanish fleet land in Cornwall, raid Penzance and environs, hold a mass and sail away
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AD 1596
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Second Spanish Armada destroyed by storm before it reaches British Isles
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AD 1596
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Felipe II is bankrupted by wars
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AD 1597
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Third Spanish Armada fails to reach British Isles
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AD 1598
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Death of Felipe II; Felipe III becomes king of Spain and (as Felipe II) of Portugal and Algarves
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AD 1618
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Beginning of Thirty Years' War: Spain supports the Habsburgs
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AD 1621
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Death of Felipe III; Felipe IV becomes king of Spain and (as Felipe III) of Portugal and Algarves
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AD 1621
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Spain's truce with the Protestant northern Netherlands ends and war resumes
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AD 1622
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Death and canonisation of Teresa of Ávila
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AD 1635
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Louis XIII of France declares war on Spain
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AD 1640
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Wars in Portugal and Catalonia
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AD 1640
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Portugal gains independence from Spain
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AD 1640
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João IV becomes king of Portugal and Algarves
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AD 1641
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France joins Portugal in alliance against Spain
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AD 1648
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End of Thirty Years' War: Spain recognises Dutch independence
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