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AD 1500
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Treaty of Granada gives Naples to France and Sicily to Aragon/Spain
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AD 1502
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War breaks out between the French and Spanish over Naples
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AD 1503
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Death of Pope Alexander VI and overthrow of Cesare Borgia
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AD 1506
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Pope Julius II takes Ravenna, Perugia and Bologna
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AD 1510
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Pope Julius changes sides and attacks French allies Ferrara and Modena
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AD 1512
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The French leave Italy; the Holy League's Congress of Mantua gives Parma and Piacenza to the pope, Milan to the Sforza, and the Medici return to Florence
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AD 1513
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Election of Giovanni de' Medici as Pope Leo X
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AD 1515
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Francis I of France invades Italy and takes Milan, Parma and Piacenza
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AD 1522
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With papal support, Emperor Charles V drives the French from Milan and Genoa
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AD 1525
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Francis I of France's invasion is crushed at the Battle of Pavia, where he is captured by forces of Emperor Charles V
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AD 1526
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Pope Clement V forms the League of Cognac against Charles V and war breaks out
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AD 1527
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The Sack of Rome by imperial troops; the pope is taken prisoner; Florence expels the Medici and Charles V is dominant in Italy
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AD 1528
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In the Treaty of Cambrai Francis I renounces all Italian claims
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AD 1530
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Medici family restored to Florence; end of the Florentine republic
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AD 1530
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Charles V crowned Holy Roman Emperor
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AD 1530
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Duchies of Savoy, Ferrara, Mantua, Urbino, Modern and Parma established
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AD 1532
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Alessandro de' Medici made hereditary duke of Florence
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AD 1535
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Death of Francesco II Sforza of Milan; Charles V occupies the duchy
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AD 1536
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Francis I of France conquers Savoy and Piedmont, seeking to gain Milan
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AD 1537
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Assassination of Alessandro de' Medici; Cosimo I de' Medici becomes duke of Florence
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AD 1540
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Charles V makes his son Philip of Spain duke of Milan
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AD 1542
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Pope Paul III establishes the Roman Inquisition
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AD 1545
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Summoned by Pope Paul III, the Council of Trent (Trento) opens
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AD 1551
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Henry II of France intervenes in Italy
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AD 1555
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Emperor Charles V abdicates and Philip II of Spain becomes duke of Milan and king of Sicily
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AD 1556
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Pope Paul IV allies with France against Philip II
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AD 1557
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Siena falls to the Spanish and is sold to Cosimo I de' Medici
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AD 1557
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Pope Paul IV come to terms with Philip II of Spain
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AD 1559
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The Peace of Câteau-Cambrécis ends the Italian Wars
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AD 1563
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Emmanuel Philibert moves his capital to Turin
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AD 1564
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Pope Pius IV publishes the decrees of the Council of Trent and promulgates a definition of Roman Catholicism
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AD 1569
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Cosimo de' Medici is elevated from duke of Florence to grand duke of Tuscany
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AD 1571
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Pope Pius V forms a league with Spain, Venice and the Knights of Malta against the Turks which wins the Battle of Lepanto
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AD 1573
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Peace is agreed between Venice and the Ottoman Sultan, in which Venice cedes Cyprus
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AD 1574
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Francesco I de' Medici becomes Grand Duke of Tuscany
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AD 1582
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Pope Gregory XIII proclaims the reformed Gregorian calendar
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AD 1592
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Pompeii is discovered
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AD 1595
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Pope Clement VIII recognises Henry IV as king of France
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AD 1598
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Pope Clement VIII seizes Ferrara on the death of the last Este, Duke Alfonso II
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AD 1600
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Henry IV of France invades Savoy to recover Saluzzo
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AD 1602
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Last attempt by the duke of Savoy to annex Geneva
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AD 1618
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The Duke of Osuna, Spanish viceroy of Naples, attacks Venice with the connivance of the viceroy of Milan
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AD 1626
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Duchy of Urbino is incorporated into the Papal States
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AD 1627
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Death of Vincenzo II, Duke of Mantua; the heir is the French duke of Nevers, and the War of the Mantuan Succession begins between France and Spain
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AD 1631
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Treaty of Cherasco ends the War of the Mantuan Succession; Charles of Nevers receives Mantua, but cedes part of Montferrat to Savoy
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AD 1636
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The French and Savoyards defeat the Spanish at the Battle of Tornavento,
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AD 1641
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First War of Castro between Pope Urban VIII and Odoardo, Duke of Parma, supported by Venice, Modena and Tuscany
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AD 1644
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Papal defeat in the War of Castro; the Duke of Parma is fully restored
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AD 1649
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Second War of Castro between Pope Innocent X and Ranuccio II, Duke of Parma results in the land around Castro being ceded to the Papal States
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