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AD 1254
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Death of Conrad IV; Conradin becomes king of Sicily and Holy Roman Emperor
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AD 1258
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Manfred, illegitimate son of Frederick II, seizes throne of Sicily
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AD 1263
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Charles of Anjou seizes Sicily
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AD 1281
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Pope Martin IV and Venice support Charles of Anjou against the Byzantine empire
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AD 1282
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Aragon takes crown of Sicily
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AD 1285
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Death of Charles of Anjou and Pedro III of Aragon; succeeded by Charles II in Naples and James in Sicily
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AD 1299
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Matteo Visconti negotiates an end to the long war between Venice and Genoa in the eastern Mediterranean
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AD 1303
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Friction between Philip IV of France and Pope Boniface VIII turns into war, the pope is attacked at Anagni, and dies of shock
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AD 1305
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The cardinals elect Pope Clement V
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AD 1308
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Start of the War of the Ferrarese Succession between the pope and Venice (until 1310)
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AD 1309
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Papal residence at Avignon begins
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AD 1311
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Henry VII is crowned king of Italy in Milan
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AD 1312
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Henry VII crowned Holy Roman Emperor at Rome
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AD 1327
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Louis IV invades Italy after papal forces take Parma, Modena and Bologna
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AD 1328
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Louis crowned Holy Roman Emperor in Rome, Pope John XXII declares a crusade against him
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AD 1339
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Simone Boccanegra elected first Doge of Genoa
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AD 1354
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Florence, Siena, Perugia and Venice ally against Milan
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AD 1355
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Genoa makes peace with Venice
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AD 1356
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Simone Boccanegra reclaims his position as Doge of Genoa after leading the expulsion of the Milanese
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AD 1376
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Florence organises a league in the Papal State and Pope Gregory XI excommunicates the city, beginning the 'War of the Eight Saints'
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AD 1377
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Pope Gregory XI moves to Rome
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AD 1378
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Beginning of the Great Schism as two popes are elected, Urban VI in Rome and Clement VII who eventually returned to Avignon
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AD 1392
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The League of Bologna is formed by Italian cities threatened by Milan
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AD 1394
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France takes over Genoa
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AD 1404
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Venice takes over Verona and Vicenza
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AD 1405
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Padua surrenders to Venice
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AD 1406
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Florence conquers Pisa
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AD 1408
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Ladislas of Naples occupies Rome
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AD 1409
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Opening of the Council of Pisa, which deposes both popes (who refuse to accept the decision) and elects a third, Alexander V
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AD 1409
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Martin I of Aragon becomes king of Sicily
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AD 1417
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The Council of Constance elects Pope Martin V: end of the Great Schism
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AD 1420
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Pope Martin V restores Rome as the papal residence
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AD 1423
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Florence declares war on Milan (until 1454)
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AD 1434
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Cosimo de' Medici becomes effective ruler of Florence
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AD 1443
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Alfonso V of Aragon and Sicily takes Naples, expelling King Rene of Anjou
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AD 1450
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Francesco Sforza is accepted as duke by the Milanese
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AD 1454
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The Peace of Lodi ends the long war between Milan, Florence and Venice; they establish a league which is joined by the pope and king of Sicily
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AD 1458
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The French occupy Genoa; Alfonso V dies and is succeeded by Ferrante in Naples and John II in Sicily and Aragon
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AD 1464
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Death of Cosimo de' Medici; his son Piero takes control of Florence
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AD 1469
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Death of Piero de' Medici; his sons Lorenzo the Magnificent and Giuliano take power in Florence
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AD 1471
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Pope Paul II makes Borso d'Este duke of Ferrara
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AD 1479
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Lodovico il Moro Sforza takes power in Milan
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AD 1480
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Lorenzo de' Medici negotiates a peace with Naples, which the pope, Milan and Venice join; the Turks take Otranto
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AD 1481
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Naples expels the Turks from Otranto
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AD 1492
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Rodrigo Borgia is elected Pope Alexander VI
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AD 1494
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Death of Ferrante of Naples; Charles VIII of France claims the kingdom and invades Italy: start of 'Italian Wars'
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AD 1494
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Republican party, influenced by Savonarola, expel the Medici from Florence
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AD 1496
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Emperor Maximilian I enters Italy to remove the remaining French
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AD 1498
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In Florence Savonarola is overthrown and burnt as a heretic
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AD 1499
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Louis XII of France overthrows the Sforza and claims Milan
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